SidaGhanaV1, Main, Exploration, bibRecord, 001372

Analysis of the immunological humoral response to Mycobacterium tuberculosis glycolipid antigens (DAT, PGLTb1) for diagnosis of tuberculosis in HIV-seropositive and -seronegative patients

Identifieur interne : 001372 ( Main/Exploration ); précédent : 001371; suivant : 001373

Analysis of the immunological humoral response to Mycobacterium tuberculosis glycolipid antigens (DAT, PGLTb1) for diagnosis of tuberculosis in HIV-seropositive and -seronegative patients

Auteurs : N. Simonney [France] ; J. M. Molina [France] ; M. Molimard [France] ; E. Oksenhendler [France] ; C. Perronne [France] ; P. H. Lagrange [France]

Source :

European Journal of Clinical Microbiology and Infectious Diseases [ 0934-9723 ] ; 1995-10-01.

RBID : ISTEX:3931DE6FFF13D30F7F18FBEEACAC0B84F0090D10

English descriptors

Abstract

Abstract: Using an enzyme immunoassay (EIA) test, the concentrations of IgG antibodies against 2,3 diacyl trehalose (DAT) and phenolic glycolipid Tb1 (PGLTb1) were measured in the sera of 153 patients with active tuberculosis, 50 of whom were coinfected with HIV, and in the sera of 152 healthy blood donors, 149 asymptomatic HIV-seropositive patients, 12 HIV-seronegative patients with conditions simulating tuberculosis, 23 HIV-seropositive patients with disseminated infection caused by mycobacteria other than tuberculosis and 24 HIV-seropositive patients with pulmonary disease from whom mycobacteria was not isolated in culture. A slightly lower percentage (74 %) of the HIV-seropositive than the HIV-seronegative (77 %) tuberculosis patients were positive for anti-DAT and antiPGLTb1 IgG antibodies, with a specificity ranging from 91 to 95 %. There was no significant difference between EIA sensitivity in smear-positive and smear-negative patients with pulmonary tuberculosis for all HIV immune statuses and sites of disease (pulmonary vs. extrapulmonary). In HIV-seropositive patients, however, sensitivity was always lower for disseminated tuberculosis than for localized tuberculosis. Combining data for both the smear test and the EIA maximized sensitivity. The main value of the EIA test could be to provide early complementary information by antibody detection in patients with tuberculosis, particularly those with a negative smear test.

Url:

https://api.istex.fr/document/3931DE6FFF13D30F7F18FBEEACAC0B84F0090D10/fulltext/pdf

DOI: 10.1007/BF01691495

Affiliations:

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to stream Main, to step Curation: 001372

Le document en format XML

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<author><name sortKey="Molina, J M" sort="Molina, J M" uniqKey="Molina J" first="J. M." last="Molina">J. M. Molina</name>
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<author><name sortKey="Molimard, M" sort="Molimard, M" uniqKey="Molimard M" first="M." last="Molimard">M. Molimard</name>
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<author><name sortKey="Oksenhendler, E" sort="Oksenhendler, E" uniqKey="Oksenhendler E" first="E." last="Oksenhendler">E. Oksenhendler</name>
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<author><name sortKey="Perronne, C" sort="Perronne, C" uniqKey="Perronne C" first="C." last="Perronne">C. Perronne</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Active tuberculosis</term>
<term>Aids patients</term>
<term>American review</term>
<term>Antibody assay</term>
<term>Antigen</term>
<term>Assay</term>
<term>Asymptomatic</term>
<term>Asymptomatic individuals</term>
<term>Asymptomatic patients</term>
<term>Clinical microbiology</term>
<term>Conditions simulating tuberculosis</term>
<term>Confirmatory tests</term>
<term>Cutoff</term>
<term>Cutoff point</term>
<term>Cutoff values</term>
<term>Diagnostic values</term>
<term>England journal</term>
<term>Enzyme immunoassay</term>
<term>Enzymelinked immunosorbent assay</term>
<term>European journal</term>
<term>Experimental immunology</term>
<term>Extrapulmonary</term>
<term>Extrapulmonary cases</term>
<term>Extrapulmonary disease</term>
<term>Extrapulmonary tuberculosis</term>
<term>Gelatin</term>
<term>Glycolipid</term>
<term>Glycolipid antigens</term>
<term>Glycolipids</term>
<term>Healthy blood donor controls</term>
<term>Healthy blood donors</term>
<term>Healthy controls</term>
<term>High percentage</term>
<term>Hivpositive patients</term>
<term>Hivseronegative patients</term>
<term>Hivseropositive</term>
<term>Hivseropositive patients</term>
<term>Human immunodeficiency virus infection</term>
<term>Humoral response</term>
<term>Immune status</term>
<term>Infectious diseases</term>
<term>Lung disease</term>
<term>Medical microbiology</term>
<term>Microbiology</term>
<term>Mycobacterial</term>
<term>Mycobacterium</term>
<term>Mycobacterium tuberculosis</term>
<term>Mycobacterium tuberculosis glycolipid antigens</term>
<term>Optical density</term>
<term>Optical density values</term>
<term>Overall sensitivity</term>
<term>Pgltbl</term>
<term>Pgltbl antigens</term>
<term>Positive percent sensitivity</term>
<term>Positive percent specificity</term>
<term>Preliminary results</term>
<term>Pulmonary disease</term>
<term>Pulmonary tuberculosis</term>
<term>Respiratory diseases</term>
<term>Saturating buffer</term>
<term>Serodiagnosis</term>
<term>Serological</term>
<term>Serological diagnosis</term>
<term>Serological methods</term>
<term>Serological responses</term>
<term>Seronegative patients</term>
<term>Serum diluent</term>
<term>Significant difference</term>
<term>Similar results</term>
<term>Single antigen</term>
<term>Smear</term>
<term>Smear test</term>
<term>Specific antibodies</term>
<term>Tuberculosis</term>
<term>Tuberculosis extrapulmonary tuberculosis</term>
<term>Tuberculosis patients</term>
<term>Various study groups</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Active tuberculosis</term>
<term>Aids patients</term>
<term>American review</term>
<term>Antibody assay</term>
<term>Antigen</term>
<term>Assay</term>
<term>Asymptomatic</term>
<term>Asymptomatic individuals</term>
<term>Asymptomatic patients</term>
<term>Clinical microbiology</term>
<term>Conditions simulating tuberculosis</term>
<term>Confirmatory tests</term>
<term>Cutoff</term>
<term>Cutoff point</term>
<term>Cutoff values</term>
<term>Diagnostic values</term>
<term>England journal</term>
<term>Enzyme immunoassay</term>
<term>Enzymelinked immunosorbent assay</term>
<term>European journal</term>
<term>Experimental immunology</term>
<term>Extrapulmonary</term>
<term>Extrapulmonary cases</term>
<term>Extrapulmonary disease</term>
<term>Extrapulmonary tuberculosis</term>
<term>Gelatin</term>
<term>Glycolipid</term>
<term>Glycolipid antigens</term>
<term>Glycolipids</term>
<term>Healthy blood donor controls</term>
<term>Healthy blood donors</term>
<term>Healthy controls</term>
<term>High percentage</term>
<term>Hivpositive patients</term>
<term>Hivseronegative patients</term>
<term>Hivseropositive</term>
<term>Hivseropositive patients</term>
<term>Human immunodeficiency virus infection</term>
<term>Humoral response</term>
<term>Immune status</term>
<term>Infectious diseases</term>
<term>Lung disease</term>
<term>Medical microbiology</term>
<term>Microbiology</term>
<term>Mycobacterial</term>
<term>Mycobacterium</term>
<term>Mycobacterium tuberculosis</term>
<term>Mycobacterium tuberculosis glycolipid antigens</term>
<term>Optical density</term>
<term>Optical density values</term>
<term>Overall sensitivity</term>
<term>Pgltbl</term>
<term>Pgltbl antigens</term>
<term>Positive percent sensitivity</term>
<term>Positive percent specificity</term>
<term>Preliminary results</term>
<term>Pulmonary disease</term>
<term>Pulmonary tuberculosis</term>
<term>Respiratory diseases</term>
<term>Saturating buffer</term>
<term>Serodiagnosis</term>
<term>Serological</term>
<term>Serological diagnosis</term>
<term>Serological methods</term>
<term>Serological responses</term>
<term>Seronegative patients</term>
<term>Serum diluent</term>
<term>Significant difference</term>
<term>Similar results</term>
<term>Single antigen</term>
<term>Smear</term>
<term>Smear test</term>
<term>Specific antibodies</term>
<term>Tuberculosis</term>
<term>Tuberculosis extrapulmonary tuberculosis</term>
<term>Tuberculosis patients</term>
<term>Various study groups</term>
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<front><div type="abstract" xml:lang="en">Abstract: Using an enzyme immunoassay (EIA) test, the concentrations of IgG antibodies against 2,3 diacyl trehalose (DAT) and phenolic glycolipid Tb1 (PGLTb1) were measured in the sera of 153 patients with active tuberculosis, 50 of whom were coinfected with HIV, and in the sera of 152 healthy blood donors, 149 asymptomatic HIV-seropositive patients, 12 HIV-seronegative patients with conditions simulating tuberculosis, 23 HIV-seropositive patients with disseminated infection caused by mycobacteria other than tuberculosis and 24 HIV-seropositive patients with pulmonary disease from whom mycobacteria was not isolated in culture. A slightly lower percentage (74 %) of the HIV-seropositive than the HIV-seronegative (77 %) tuberculosis patients were positive for anti-DAT and antiPGLTb1 IgG antibodies, with a specificity ranging from 91 to 95 %. There was no significant difference between EIA sensitivity in smear-positive and smear-negative patients with pulmonary tuberculosis for all HIV immune statuses and sites of disease (pulmonary vs. extrapulmonary). In HIV-seropositive patients, however, sensitivity was always lower for disseminated tuberculosis than for localized tuberculosis. Combining data for both the smear test and the EIA maximized sensitivity. The main value of the EIA test could be to provide early complementary information by antibody detection in patients with tuberculosis, particularly those with a negative smear test.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
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<name sortKey="Lagrange, P H" sort="Lagrange, P H" uniqKey="Lagrange P" first="P. H." last="Lagrange">P. H. Lagrange</name>
<name sortKey="Molimard, M" sort="Molimard, M" uniqKey="Molimard M" first="M." last="Molimard">M. Molimard</name>
<name sortKey="Molina, J M" sort="Molina, J M" uniqKey="Molina J" first="J. M." last="Molina">J. M. Molina</name>
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Analysis of the immunological humoral response to Mycobacterium tuberculosis glycolipid antigens (DAT, PGLTb1) for diagnosis of tuberculosis in HIV-seropositive and -seronegative patients

Analysis of the immunological humoral response to Mycobacterium tuberculosis glycolipid antigens (DAT, PGLTb1) for diagnosis of tuberculosis in HIV-seropositive and -seronegative patients

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri